10 Ways Methamphetamine RAVAGES the BRAIN - The Neuroscientific Mechanisms

In this video, we dissect the profound impact of methamphetamine on the brain, offering a thorough analysis from a neurobiological standpoint. We examine how methamphetamine, even in a single dose, can initiate a complex series of neurobiological events, leading to various short-term and long-term changes in brain structure and function. These changes can be subtle or significant, and they differ from person to person.

0:00 Methamphetamine's effects on the brain
4:36 Methamphetamine's Neural Adaptations Leading to Addiction
9:12 Behavioural Sensitisation and Reverse Tolerance with Methamphetamine
13:22 Methamphetamine's effects on dopamine, cognition, and brain structure
19:01 Methamphetamine and Neuroinflammation
22:06 Methamphetamine and Neurodegeneration

We'll navigate through how methamphetamine disrupts neurotransmitter regulation, leading to synaptic plasticity changes and altered neuronal excitability. The drug's interaction with dopamine, serotonin, and noradrenaline transport systems will be discussed, including its effects on the enzyme monoamine oxidase (MAO) and how this contributes to its hyperstimulating properties. We'll also explore how methamphetamine's chronic use leads to a cascade of addiction through the mesolimbic pathway and the resultant neuroadaptations that make recovery challenging.

We touch on the behavioural, cardiovascular, and neurotoxic effects of methamphetamine, delving into how it affects everything from neurotransmitter levels to cognitive functions and even the body's stress responses.

By understanding these mechanisms, we aim to shed light on the science behind methamphetamine's powerful grip on the brain and why it's considered a significant public health challenge.

Don't forget to leave a like, drop your comments, and let us know which topics you'd like us to cover next. Your support is greatly appreciated. Stay curious and see you in the next video!


#MethamphetamineEffects
#BrainHealth
#Neuroscience
#AddictionScience
#DrugAwareness
#PsychiatryEducation
#Neurobiology
#DopamineDysregulation
#MethAddiction
#RecoveryJourney
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