Huntington Disease | A Clinical Medicine Brief

🧠 NEURO101: Huntington Disease | Clinical Medicine Brief
In this NEURO101 episode of the Pro-PA Podcast, Dr. G dives into Huntington Disease—a devastating, inherited neurodegenerative disorder that affects both movement and cognition, and one that every PA student should know for the PANCE and beyond.

🧬 Caused by a CAG trinucleotide repeat expansion in the HTT gene, Huntington Disease follows an autosomal dominant inheritance pattern, with symptoms usually beginning in mid-adulthood.

🎯 In this Clinical Medicine Brief, we’ll cover:

What is Huntington Disease? (Kinder Patho explained)

Clinical triad: chorea, psychiatric changes, and dementia

Onset and progression: subtle mood changes → movement symptoms → cognitive decline

Diagnosis: clinical suspicion + genetic testing

Imaging clues: caudate nucleus atrophy on CT/MRI

Management: supportive care, tetrabenazine for chorea, genetic counseling

This is a high-yield neurology topic with real-world implications—especially when evaluating patients with family history of early-onset dementia or psychiatric decline.

🎧 Listen to the Pro-PA Podcast:
https://open.spotify.com/show/2gn5uJP...
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