A Cure for Obesity? Exclusive Interview with Fractyl Health’s CEO
Автор: DOWNSIZED
Загружено: 2025-11-18
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A Cure for Obesity? Interview with Dr. Harith Rajagopalan
Can obesity really be cured? In this exclusive interview filmed live from the ObesityWeek conference in Atlanta, Dr. Harith Rajagopalan, cardiologist, scientist, and CEO of Fractyl Health, joins Christopher Durham from The Downsized to talk about groundbreaking new therapies that target the root causes of obesity through the gut and pancreas.
Dr. Rajagopalan explains how his company’s innovative treatments — including the Revita endoscopic procedure and the Rejuva platform — could one day help patients rewire the brain–gut connection, maintain weight loss without weekly GLP-1 injections, and potentially heal the disease of obesity.
If you’ve ever wondered what comes after GLP-1s like Zepbound, Mounjaro, and Wegovy… this conversation offers a hopeful look at the future.
00:00 Welcome to the Downsized
00:47 Introduction to Harith Rajagopalan
01:19 Harith's Journey into Obesity Medicine
02:38 Personal Stories and Motivation
03:37 Challenges in Treating Obesity
04:49 The Role of Bariatric Surgery
07:34 Introducing Fractyl Health
08:36 Understanding the Brain-Gut Connection
13:31 Innovative Therapies for Obesity
18:08 Future Prospects and Clinical Trials
21:40 Comparing Bariatric Surgery and Tirzepatide
22:29 Insurance and the Cost of GLP-1 Medications
24:52 Therapy Number Two: RejuVa Platform
27:19 Mechanism of RejuVa and GLP-1 Hormones
29:29 Clinical Trials and Future Prospects
31:39 Hope and Future Innovations in Obesity Treatment
36:26 Conclusion and Final Thoughts
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