[Conférence] E. MIGNOT - Cause de la narcolepsie
Автор: Académie des sciences
Загружено: 2019-02-18
Просмотров: 3981
Conférence : Hommage à Michel Jouvet
Lien de la conférence : https://www.academie-sciences.fr/fr/C...
00:00:00 Introduction
00:01:01 Human narcolepsy-cataplexy, a REM sleep and wakefulness disorder
00:07:56 Genetic epidemiology is consistent with Autoimmunity
00:13:30 Many canine narcolepsy cases are genetically transmitted as a single gene
00:15:58 Hypocretin receptor [Hcrtr2] Mutations in genetic forms of narcolepsy in canines
00:17:33 Truncated receptors in canine narcolepsy
00:17:55 1998: Hypocretin/orexins discovered
00:18:45 Hypocretin deficiency in sporadic, HLA positive adolescent onset narcolepsy cases
00:20:31 Normal hypocretin and receptors
00:20:47 Hypocretin deficiency and receptors
00:21:11 Next question: Why are hypocretin-producing cells missing in human narcolepsy?
00:22:32 Manhattan GWAS in 5,500 narcolepsy
00:23:40 One environmental factor: flu
00:24:16 HLA-peptide-TCR
00:25:35 Hypocretin Agonist
00:26:05 Conclusion
00:27:14 Our inspiration
00:27:60 Questions
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