Innate Immunity and Microbiome of the Human Female Reproductive Tract

Presented By: Mimi Ghosh, PhD, MS

Speaker Biography: Dr. Ghosh received her PhD from the University of Pittsburgh, School of Public Health in Infectious Diseases and Microbiology. Following her PhD, she pursued post-doctoral training at the Geisel School of Medicine at Dartmouth focusing on HIV acquisition and transmission in women. Currently Dr. Ghosh is an Associate Professor at the George Washington University, Milken Institute School of Public Health. Her research interests are focused on HIV in vulnerable populations, specifically immune responses and its regulation by sex hormones. Her current projects are funded by NIH and CFAR and include working with adolescent girls, postmenopausal women, women who have experienced sexual violence and trauma as well as transgender individuals.

Webinar: Innate Immunity and Microbiome of the Human Female Reproductive Tract

Webinar Abstract: Globally, women are disproportionately affected by sexually transmitted infections (STI) including HIV. The immune system of the female reproductive tract (FRT) balances the unique role of providing protection against pathogens while ensuring successful reproduction to occur. FRT immunity is multi-layered and intricately regulated by sex hormones estrogen and progesterone. The vaginal microbiome plays a major role in the protection of the FRT and dysbiosis of the microbiome can lead to bacterial vaginosis, which makes women susceptible to HIV/STI. The objective of this presentation is to provide an overview of the innate immune responses of the human FRT and discuss how microbial dysbiosis can compromise women’s health.

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