Chronic Myeloid Leukemia (CML) | Pathogenesis, Symptoms and Treatment

Lesson on Chronic Myeloid Leukemia (CML): Pathogenesis, Symptoms and Treatment. Chronic Myeloid (or Myelogenous) Leukemia (CML) is one type of leukemia, which is a blood cancer with high levels of white blood cells. CML is a leukemia with proliferation of mature neutrophils (PMNs), as evidenced by white blood cells with large nuclei on a blood smear or peripheral blood film. CML often presents asymptomatically, but can progress to having characteristic signs and symptoms of splenomegaly, constitutional symptoms, and lower sternum tenderness.

Pathogenesis of CML is due to the Philadelphia Chromosome, which is a product of translocation of chromosomes 9 and 22, leading to a new fusion gene and protein product. This new protein (BCR-ABL) is an activated tyrosine kinase, which leads to activation of cellular survival and proliferation pathways.

Treatment of CML involves a drug known as imatinib, which has been designed to specifically target the BCR-ABL fusion protein.

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Please also check out some of my other hematology videos!

JJ

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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JJ