Oxidative Stress: The Cellular Damage You Didn't Know About

This video clarifies how `oxidative stress` and `reactive oxygen species` can lead to `cellular damage`, even in perfectly planned `dental implant` cases. We examine the underlying `biology` of these processes and their impact on healing, emphasizing that `inflammation` can contribute to `surgical complications` despite ideal initial conditions. Understanding these factors is crucial for improved patient outcomes.

Chapters:
00:00 Intro


#ImplantDentistry
#DentalImplants
#OralSurgery
#BoneGrafting
#GuidedBoneRegeneration
#OxidativeStress
#BiologicImplantSurgery
#NIRLightTherapy
#Photobiomodulation
#Osseointegration
#PRF
#SurgicalTips
#DentalEducation

REFERENCES:

Core Biology & Oxidative Stress
1. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 5th ed. Oxford: Oxford University Press; 2015.
2. Sena LA, Chandel NS. Physiological roles of mitochondrial reactive oxygen species. Mol Cell. 2012;48:158–167.
3. Sies H, Jones DP. Reactive oxygen species in human biology. Antioxid Redox Signal. 2020;33:235–257.
4. Domazetovic V, et al. Oxidative stress in bone remodelling. Clin Cases Miner Bone Metab. 2017;14:209–216.

Bone, Implants & Peri-Implant Disease
5. Ahmadi M, Ahmadieh A. Oxidative stress and peri-implant disease. Clin Implant Dent Relat Res. 2021;23:915–928.
6. Tsamesidis I, et al. Oxidative stress markers in peri-implantitis. Clin Oral Investig. 2023;27:81–94.
7. Almeida M, et al. Oxidative stress and skeletal involution. J Clin Invest. 2007;117:2036–2048.
8. Manolagas SC. Aging, oxidative stress, and bone loss. Endocr Rev. 2010;31:266–300.

Angiogenesis, Microcirculation & Healing
9. Manresa C, et al. Endothelial function and bone regeneration around implants. Clin Oral Implants Res. 2017;28:1154–1161.
10. Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89:219–229.


Systemic Factors: Exercise & Metabolic Health
11. Radak Z, et al. Exercise, oxidative stress and hormesis. Ageing Res Rev. 2017;39:90–99.
12. Pedersen BK. Physical inactivity and systemic inflammation. J Physiol. 2009;587:5559–5568.
13. Lin X, et al. Diabetes impairs bone regeneration via oxidative stress. J Bone Miner Res. 2019;34:1153–1168.

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Intermittent Fasting & Metabolic Flexibility
14. Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014;19:181–192.
15. de Cabo R, Mattson MP. Effects of intermittent fasting on health and disease. N Engl J Med. 2019;381:2541–2551.

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Photobiomodulation / Near-Infrared (NIR) Light
16. Karu TI. Mitochondrial mechanisms of photobiomodulation. Photomed Laser Surg. 2010;28:159–160.
17. Hamblin MR. Photobiomodulation: cellular responses to NIR light. J Photochem Photobiol B. 2018;190:35–44.
18. Chung H, et al. The nuts and bolts of low-level light therapy. Ann Biomed Eng. 2012;40:516–533.
19. Maia ML, et al. Low-level laser therapy in bone healing: systematic review. Photomed Laser Surg. 2010;28:589–594.

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Bone Grafts, Porosity & Stability
20. Traini T, et al. Histological analysis of xenogenic bone substitutes. Clin Oral Implants Res. 2007;18:819–826.
21. Sartori S, et al. Porosity and vascularisation in bone substitutes. Clin Oral Implants Res. 2003;14:532–539.
22. Cordaro L, et al. Graft stability and tension-free closure in GBR. Clin Oral Implants Res. 2002;13:114–121.