Lecture17 - Disease GWAS PRS Mechanism - MLCB24
Автор: Manolis Kellis
Загружено: 2024-11-06
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Playlist: https://tinyurl.com/MLCBlectures
Notes: https://tinyurl.com/MLCB24notes
Lecture Slides: https://www.dropbox.com/scl/fi/uutwoa...
Lecture Chapter: https://www.dropbox.com/scl/fi/5lixm0...
00:00 Genetics: From Ancient Times to Today
17:07 Disease-associated Variants
19:19 Challenge of Mechanism
21:25 Variation and Disease
25:49 Defining Variants
31:18 Common Variants and Haplotype Blocks
38:03 GWAS Genome-wide Association Studies: Genotype-Phenotype
50:52 Common/weak-effect vs. Rare/Strong-effect variants
59:06 Family studies (Linkage Analysis) vs. Unrelated Individuals (GWAS)
1:04:05 Population Differences, Ancestry Painting, PCA, Multi-Ethnic Fine-Mapping
1:12:41 Polygenic Scores (PGS) and Polygenic Risk Scores (PRS)
1:18:53 Mechanistic Insights from Genome-Wide Functional Enrichments
1:25:18 Summary
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![[Shing Wan Choi] Tutorial: Polygenic Risk Score (PRS) Analyses](https://ricktube.ru/thumbnail/bgWWr2nWe3Q/mqdefault.jpg)
