If you’re a doctor, healthcare professional, or a parent seeking to understand why leucovorin (also known as folinic acid) is becoming a hot topic in autism care, this is the video you need to watch.
Dr. Theresa Lyons—Yale-trained PhD and dedicated autism science translator—dives into the growing interest around leucovorin for autistic children, especially as shared in viral TikTok and social media stories. This video offers clinicians a high-level, research-driven summary (with all the key studies referenced) on the science behind folinic acid in autism, cutting through hype, anecdote, and medical hesitation.
What’s covered:
-Why parents are increasingly asking about leucovorin for their autistic children
-The peer-reviewed evidence on leucovorin use, including:
-Cerebral folate deficiency and its link to folate receptor alpha autoantibodies (FRAA)
-The blood test: when and why to use it
-International studies outlining efficacy and safety
-What the clinical trials show about speech, engagement, and daily functioning improvements
-Dose, duration, and managing parent expectations
-Minimal but important-to-understand side effects
-Why mainstream medical education hasn’t caught up—and how Dr. Lyons helps bridge that gap with trustworthy, unbiased science summaries
This video is perfect for busy clinicians wanting digestible, referenced science to inform medical decision-making, and for parents aiming to discuss evidence-based therapies with their healthcare providers.
Let Dr. Lyons help you turn the complexity of autism science into clarity for families and clinicians—ensuring better outcomes for autistic children everywhere.
00:00 Intro: Why this video exists and who it’s for
01:03 About Dr. Theresa Lyons and her mission
01:35 Rise in parent interest: Leucovorin and autism on social media
02:30 Why doctors haven’t heard much about folinic acid
03:23 Cerebral folate deficiency and the importance of the test
04:47 2009 James et al. study: B12 and folinic acid, metabolic markers
05:26 Common outcomes and side effects (hyperactivity)
05:56 2018 Frye et al. study: Pivotal research, dosing, FRAT link
06:45 2020 France study: Repetition and worldwide interest
07:21 2021 Iran study: Combination with risperidone and speech improvements
07:49 2024 India study: Longer duration and CAR scores
08:30 2025 Singapore study: Open label, control arm, and outcomes
09:36 Adverse effects: Risks with dosing and titration tips
09:57 Summary: Global clinical research and peer-reviewed evidence
10:14 Why doctors may not be up to date (systemic reasons)
11:03 Practical takeaways: Who benefits, testing, dosing, and setting expectations
11:45 Safety: Side effects, monitoring, and the importance of correct dosing
12:35 Dr. Lyons’ mission: Supporting clinicians with evidence-based resources
13:07 Closing: How to contact Dr. Lyons, accessing resources, and her commitment
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✅ If you are a parent of an autistic child, I want you to know - there is hope.
😀You and your child can smile again.
There can be laughter and connection.
So many fun times can be part of your future. You probably feel that possibility in your gut but you're not sure how to get here. Let me help guide you.
Have a follow-up question about this video? Comment below.👇
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Want to find a great autism doctor for your child? Great! I wrote a book to help you.
✅Check it out on Amazon https://amzn.to/2SlIjND
And if it's been a tough day and you’re needing some inspiration, check out my YouTube playlist on that exact topic here: 💪 • Inspiration
The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content, including text, graphics, images, and information contained in this video is for general information purposes only and does not replace a consultation with your doctor.
#autism #autismkids #autismfamily
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