Ran GTPase Cycle and Nuclear Transport | Importins and Exportins

Lesson on the Ran GTPase Cycle and the mechanism of Nuclear Transport involving importins and exportins. The Ran GTPase cycle is critically important for nuclear transportation of transcription factors and other proteins into and out of the nucleus. The RanGTPase cycle induces a Ran gradient, which leads to increased levels of RanGDP in the cytosol and RanGTP in the nucleus. Importins and their cargo, along with RanGDP enter the nucleus through nuclear pore complexes. Once inside the nucleus, RanGDP gets processed to RanGTP.

Hey everyone. In this lesson you will be introduced to the Ran GTPase cycle, what it is and why it is important. You will also learn about how proteins such as transcription factors can enter and exit the nucleus with the help of proteins known as importins and exportins, respectively.

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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