PermeabilitySeries: In vitro tools for predicting biopharmaceutical performance of drugs in vivo

How can in vitro permeability tools help predict the biopharmaceutical performance of drugs before they ever enter animal studies or clinical trials?
In this webinar from the PermeabilitySeries, Massimiliano Pio di Cagno, PhD, explains the conceptual foundations and practical use of artificial permeability barriers such as PAMPA, PermeaPad®, and other commercial high-throughput systems.

These tools allow researchers to estimate passive diffusion, screen new chemical entities, evaluate enabling formulations, and improve bioavailability predictions early in development — reducing time, cost, and the need for animal experiments.

🔍 You will learn about:

Why in vitro permeability tools matter for predicting in vivo drug performance
The concept of apparent permeability (Papp) and how it is measured
Differences between cellular barriers (e.g., Caco-2) and artificial barriers (PAMPA, PermeaPad®)
How PermeaPad® captures both transcellular and paracellular transport
Pros and cons of diffusion cells, side-by-side setups, and multiwell plate formats
How in vitro permeability data can support bioavailability, IVIVC, and formulation design
Case examples where in vitro permeability correctly predicted in vivo outcomes

🧪 Why this matters

Modern drug development requires faster, more predictive, and ethically responsible tools.
Permeability models offer a powerful way to:
Reduce preclinical timelines
Improve mechanistic understanding of absorption
Support in silico drug modeling
Reduce animal testing in line with the 3Rs principle

📈 Who should watch?

This webinar is ideal for professionals in:
Pharmaceutics
Drug delivery
ADME/PK sciences
Bioavailability prediction
Formulation development
In vitro and high-throughput screening

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