21 Lecture - MI260: Bayesian MBMA to Support Decision Making in Drug Development (2013)
Автор: MetrumRG
Загружено: 2013-11-22
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Course materials available for download here: https://www.metrumrg.com/courses/
These training resources are provided by Metrum Institute at no cost. Course materials are licensed under Creative Commons Attribution 3 (http://creativecommons.org/licenses/b.... Additional technical consulting and custom training options are available separately, from Metrum Research Group (http://metrumrg.com).
MI260 provides an introduction to meta analysis concepts and methods, with a strong focus on model-based meta-analysis of summary data or a combination of summary and individual data from clinical trials to support decision-making in clinical drug development. Upon completion of the course, participants will be able to write a meta-analysis plan, design a model-based meta-analysis of clinical trial data to address strategic decisions in a clinical drug development program, and implement it using a Bayesian approach executed with WinBUGS and R. Participants will also be able to construct a model for the relationship between an efficacy- or safety-related clinical outcome and independent variables such as dose, time and patient characteristics by analysis of summary data from multiple studies, e.g., treatment means and standard deviations, and construct such a model by analysis of a combination of summary and individual data, as well as execute and interpret population simulations to support decision-making in clinical drug development.
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