Automating UFDF Process w/ In-Line Conc Measurement to Reduce Cycling Time & Accelerate Process Dev
Автор: Repligen Process Analytical Solutions
Загружено: 2024-02-22
Просмотров: 110
Learn more at https://www.repligen.com/
In this presentation, we presented an innovative integrated system designed to automate the tangential flow filtration (TFF) process based on inline concentration measurement. This system employs in-line variable pathlength spectroscopy to acquire concentration measurements, enabling real-time monitoring and control of the process and ensuring desired results. This approach is robust and immune to the variability issues that frequently arise in mass balance-only systems. The system’s automated process control capabilities are demonstrated across a range of final concentration endpoints, indicating superior performance to traditional ultrafiltration/diafiltration (UF/DF) methods.
This new Process Analytical Technology (PAT)-driven TFF system represents a significant advancement in UF/DF technology with distinct advantages over existing methods.
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