Angiomatoid Fibrous Histiocytoma 101 (Note: it's NOT aneurysmal dermatofibroma!)

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

**For BEST quality, view in 720p HD full screen.** A discussion of the histopathologic and molecular features of angiomatoid fibrous histiocytoma. Translocations/gene fusions: EWSR1-CREB1 (90%), EWSR1-ATF1, or FUS-ATF1.

‪ Useful new info on angiomatoid fibrous histiocytoma:
They often express ALK-1 https://www.ncbi.nlm.nih.gov/pubmed/2... ; don't confuse AFH with inflammatory myofibroblastic tumor (see my video on IMT:    • IMT: Inflammatory Myofibroblastic Tumor......   )
They may express TLE-1, giving me yet another reason to dislike TLE-1! (https://pmc.ncbi.nlm.nih.gov/articles... & https://www.ncbi.nlm.nih.gov/pubmed/2... ); don't confuse AFH with synovial sarcoma (see my video on synovial sarcoma: https://kikoxp.com/posts/4105)
-They may express MUC4: https://www.ncbi.nlm.nih.gov/m/pubmed... (don’t confuse with low grade fibromyxoid sarcoma...although they usually look quite different morphologically; check out my video on LGFMS: https://kikoxp.com/posts/4189)
They may have pleomorphism or a range of other unusual histologic features. Great paper on this by my friend Summer Bohman & colleagues: https://www.ncbi.nlm.nih.gov/pubmed/2...

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

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