Advancing Biomaterials: Biomimetic and Biohybrid Innovations (2) - S. Lecommandoux (2024-2025)

Colloque 2024-2025 : Advancing Biomaterials: Biomimetic and Biohybrid Innovations
Conférence du 6 juin 2025 : Polymer-based artificial cells

Intervenant : Jan van Hest, professeur, Eindhoven University of Technology

Compartmentalization is generally regarded as one of the key prerequisites for life. To better understand its role, there is a clear need for model systems in which life-like properties can be installed. In this lecture I will discuss a synthetic cell platform composed of a complex polymer coacervate formed from oppositely charged amylose derivatives and stabilized by a semi-permeable polymer membrane. The coacervate structure resembles better the crowded environment observed in the cytoplasm than vesicular structures normally do. Cargo, such as enzymes, can be highly effectively loaded in the coacervates, based on complementary charge and affinity. This allows protocell communication with this robust synthetic platform. Using natural scaffolding proteins we can controllably take up and release proteins from the artificial environment, which mimics natural secretion. We have reconstructed the cellular architecture of a eukaryotic cell by incorporating multiple artificial organelles, both with membrane-bound and membrane-less architectures. Furthermore we have equipped the cells with an artificial cytoskeleton that allows us to modulate membrane dynamics and mechanical properties. Finally, we are able to incorporate life-like features such as motility in these structures, making this class of artificial cells a very versatile platform to study and mimic biological processes.

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Chaire Innovation technologique Liliane Bettencourt
Professeur : Sébastien Lecommandoux

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