Advanced Organic Chemistry: Retrosynthesis with Dr. Steven Crossley

In this installment of the Synthesis Workshop Advanced Organic Chemistry course, we start our Synthesis module as Dr. Steven Crossley joins us to talk about retrosynthesis.

References (in order of appearance):
Corey, E.J.; Cheng, X.-M. The Logic of Chemical Synthesis, 1995 Wiley; Corey, E.J. Chem. Soc. Rev. 1998, 17, 111.
Chem. Rev. 2015, 115, 9465; JACS 2020, 142, 11376; ACIE 2020, 59, 13734.
Grossman, R.B. The Art of Writing Reasonable Organic Reaction Mechanisms, 2003 Springer.
Böttcher, T. Chem. Inf. Model. 2016, 56, 462.; Shenvi, R.A. & co. JACS 2020, 142, 18599.
Link to plug in SMILES code of molecule into a calculator (https://forlilab.org/services/bottcher/) to generate the Cm value.
For a recent demonstration, see: Yingfu Lin, Rui Zhang, Di Wang, and Tim Cernak. Computer-aided key step generation in alkaloid total synthesis. Science, 2023, 379, 453-457.
See Hutchinson, A.J.; Kishi, Y. JACS 1979, 101, 6786; Baran, P.S.; Corey, E.J. JACS 2002, 124, 7904.
Wei, H.; Qiao, C.; Liu, G.; Yang, Z.; Li, C-C. ACIE 2013, 52, 620; Hughes, J. 2018, Thesis Part I. I. A Total Synthesis of (−)-Virosaine A, McGill University.
Haelsig, K.T.; Xuan, J.; Maimone, T.J. J. Am. Chem. Soc. 2020, 142(3), 1206.
See Shenvi, R.A. & co. JACS 2020, 142, 11376; Maimone, T. & co. Chem. Rev. 2017, 117, 11753.