Dentist Reveals Exciting Research Findings Involving Rapamycin on Oral Health | 5 - Jon An, DDS, PhD

Subscribe to our channel:    / @optispan  

Matt and guest Jonathan An, Assistant Professor of Oral Health Sciences at the University of Washington School of Dentistry, discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode.

0:00 Are there any longevity interventions that are demonstrably effective for improving oral health?
1:55 What is the connection between aging and oral health?
4:09 What normal aging in a mouse looks like chronologically/studying aging in animal models
11:45 How Jonathan started out approaching the topic of periodontal disease in aged mice
14:00 Jonathan's study: Rapamycin treatment attenuates age-associated periodontitis disease in mice
28:12 Jonathan's study: Rapamycin rejuvenates oral health in aging mice
46:05 Are the effects of rapamycin on oral health shown in the paper systemic or local? Would rapamycin toothpaste work?
49:23 What Jonathan has learned since the rejuvenation study
54:06 What do we know about rapamycin's effects on oral health in humans?
59:00 An upcoming clinical trial of rapamycin's effects on periodontal disease in humans

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

More places to find us:

Twitter:   / optispanpodcast  
Twitter:   / optispan  
Twitter:   / mkaeberlein  
Linkedin:   / optispan  

https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!