Alpha-1 Antitrypsin Deficiency Explained | Liver & Lung Damage | NRE-1 & USMLE Review|part 52
Автор: Dr Hidayat
Загружено: 2025-11-29
Просмотров: 3
Alpha-1 Antitrypsin (A1AT) Deficiency is a genetic disorder causing panacinar emphysema, cirrhosis, and neonatal jaundice due to misfolded A1AT proteins accumulating in the liver.
In this video, we cover pathophysiology, clinical features, liver vs lung symptoms, PiZZ phenotype, diagnosis, and treatment, based on high-yield USMLE Step 1 / NRE-1 concepts.
✔ Causes & genetics (SERPINA1 mutation)
✔ Role of elastase → emphysema
✔ Liver pathology: PAS-positive globules
✔ Smoking impact
✔ Screening & management
✔ High-yield exam tips
Perfect for MBBS, USMLE Step 1, FCPS Part-1, and NRE-1 students.
alpha 1 antitrypsin deficiency, A1AT deficiency, panacinar emphysema, neonatal hepatitis, PiZZ phenotype, PAS positive globules, liver disease, lung disease, usmle step 1, nre1, hepatology, pulmonology
#Alpha1AntitrypsinDeficiency #A1AT #Emphysema #LiverDisease #USMLE #NRE1 #MedicalEducation #MedStudy #HighYield
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