Genome topology - shaping genomes for transcriptional regulation - dr Aleksandra Pękowska
Автор: Polskie Towarzystwo Biochemiczne
Загружено: 2021-10-22
Просмотров: 184
Aleksandra Pękowska graduated from the University of Lodz in biology, spec. biophysics in 2006. Next, she joined Dr Pierre Ferrier’s lab at the CIML in Marseilles, where she described chromatin signatures of active enhancers and tissue specific genes. In 2011, dr Pekowska joined the group of dr Wolfgang Huber EMBL, Heidelberg. She found that loss of pluripotency coincides with a gain of chromatin loops. In 2016, dr Pekowska joined the team of Dr Rafael Casellas at the National Institute of Arthritis Musculoskeletal and Skin Diseases at the National Institutes of Health in Bethesda, she described a unique chromatin structure linked to the control of gene expression. In 2019, dr Pekowska opened the Dioscuri Center of Chromatin Biology and Epigenomics at the Nencki Institute of Experimental Biology PAS. She combines ‘omics’ tools, CRISPR-Cas9, and stem cell models to understand the genetic bases of astrocyte functions and the implication of genome topology in transcriptional regulation.
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