Hierarchical self-assembly of model primitive cells, Anna Wang, University of New South Wales

Anna Wang
Scientia Lecturer, Soft Matter and Biophysics Group Leader, School of Chemistry, University of New South Wales, Sydney

"Hierarchical self-assembly of model primitive cells"

This seminar will give an overview of how concepts from colloidal science and self-assembly can contribute to our understanding of how life originated from simple molecules. As a case study, the discussion will cover one process thought to be extremely favourable for the emergence of life: the ability for primitive cells to form networks and adhere, leading to robust communities that can share nutrients and genetic advantages. We first self-assemble solutions of giant unilamellar vesicles using fatty acids to use as a model system. The membranes are highly dynamic compared to phospholipid membranes, leading to interesting outcomes in self-assembly. The membranes also readily encapsulate RNA, and can store elastic energy. We will then discuss how the same membranes can also self-assemble into networks ranging from pairs to three-dimensional rafts. At first, the ability for the membranes to adhere appears confounding: like-charged membranes typically repel in the absence of fusogens or adhesives. We find that the observed aggregation can also be attributed to the dynamic properties of the bilayer system.

The Origins of Life Speaker Series explores the conditions and circumstances that led to the diversity of life on Earth. The interdisciplinary series will connect the formation of planets, the evolution of early Earth, and the complex chemistry and delivery of the fundamental organic molecules that serve as the building blocks of early life, and how they can establish complex, self-replicating systems of cells and genetic material. Learn more: https://physicalsciences.uchicago.edu...

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