Molecular Deep Dive: NAD⁺ | Cellular Energy, Redox Biochemistry & Research Insights

Discover the science behind NAD⁺ (Nicotinamide Adenine Dinucleotide) — a key coenzyme in cellular metabolism, DNA repair, and epigenetic regulation.
In this Molecular Deep Dive, we explore how NAD⁺ drives energy transfer, redox reactions, and cellular resilience in research models.

🔬 Molecular Deep Dive: NAD⁺

NAD⁺ — Nicotinamide Adenine Dinucleotide — is a pyridine dinucleotide central to cellular metabolism, energy transfer, and redox biochemistry.

As a hydride acceptor, NAD⁺ plays a vital role in glycolysis, the tricarboxylic acid cycle (TCA), and fatty-acid oxidation — transferring electrons that drive ATP generation.

Beyond redox activity, NAD⁺ serves as an obligate co-substrate for sirtuins, PARPs, and CD38 — enzymes linked to DNA repair, epigenetic regulation, circadian rhythm, and calcium signaling.

In this episode, we examine:
• The redox and non-redox roles of NAD⁺
• How sirtuins and PARPs regulate genomic stability
• NAD⁺ biosynthesis through de novo, Preiss–Handler, and salvage pathways
• Age-related NAD⁺ decline and mitochondrial function
• Research findings from Covarrubias et al. (2021), Li et al. (2017), Ying (2006), and Zhang et al. (2016)

NAD⁺ connects energy metabolism, enzyme regulation, and genomic maintenance — making it a cornerstone in molecular biology and research on aging.

📚 References & Citations:
Citations are included at the end of the video. Full reference list available here: https://pekcuralabs.com/shop/pcl-nad/

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