Homolactic Fermentation & Cori Cycle Explained (Lactate Dehydrogenase) | Clip

Welcome to Science With Tal!

In this video, we will discuss homolactic fermentation by describing when the pathway is utilized and by which enzymes it is carried out. Also, we will discuss the Cori cycle, which is a neat recycling mechanism that allows to recycle the lactate made from fermentation.

Here is the link for the full discussion:
   • Carbohydrate & Fat Metabolism Explained | ...  

You can consult the PDF of the metabolic map here: https://drive.google.com/file/d/1_NKQ...

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TIMESTAMPS

0:00 Introduction
0:18 Purpose of the pathway
3:50 Cori cycle
5:05 Conclusion

RESOURCES

Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)

Textbooks
1. Lodish: Molecular Cell Biology (9th ed., 2022)
2. Voet: Fundamentals of Biochemistry (5th ed., 2016)

Scientific articles
3. Webb: Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations (2015)
https://pubmed.ncbi.nlm.nih.gov/25985...

4. Crocher: Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding (2017)
https://pubmed.ncbi.nlm.nih.gov/27802...

5. Revel: Electron microscopy of glycogen (1964)
https://pubmed.ncbi.nlm.nih.gov/14187...

6. McCommis: Mitochondrial pyruvate transport: a historical perspective and future research directions (2015)
https://www.ncbi.nlm.nih.gov/pmc/arti....

7. Škerlová: Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion (2021)
https://pubmed.ncbi.nlm.nih.gov/34489...

8. Denton: The hormonal regulation of pyruvate dehydrogenase complex (1996)
https://pubmed.ncbi.nlm.nih.gov/8869747/

9. Baradaran: Crystal structure of the entire respiratory complex I (2013)
https://www.ncbi.nlm.nih.gov/pmc/arti...

10. Maier: The crystal structure of a mammalian fatty acid synthase (2008)
https://pubmed.ncbi.nlm.nih.gov/18772...

11. Saltiel: Insulin signaling in health and disease (2021)
https://pubmed.ncbi.nlm.nih.gov/33393...

12. Rahman: Role of Insulin in Health and Disease: An Update (2021)
https://pubmed.ncbi.nlm.nih.gov/34203...

13. Gao: α-cell electrophysiology and the regulation of glucagon secretion (2023)
https://pubmed.ncbi.nlm.nih.gov/37159...

CREDITS

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower (   • lukrembo - sunflower (no copyright music)  )