Superficially Porous vs Totally Porous HPLC Columns | Higher Efficiency, Lower Pressure

What’s the difference between superficially porous (SPP) and totally porous (TPP) particles in HPLC columns? In this video, we explain how column particle structure affects efficiency, separation, and pressure requirements.

You’ll learn:
• Why smaller HPLC particles increase efficiency but demand higher pressure
• How superficially porous particles (core-shell) give you UPLC-like efficiency on standard HPLC systems
• The pros and cons of SPS vs TPS columns for real-world chromatography applications

Whether you’re running a standard LC or UPLC, understanding particle technology will help you choose the right column for your method.

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