RosettaAntibodyDesign (RAbD): Walkthrough - Rosetta Virtual Workshop 2021
Автор: The Meiler Lab
Загружено: 2021-08-03
Просмотров: 2488
Dr. Benjamin Mueller provides a walkthrough of the RosettaAntibodyDesign (RAbD) tutorial..
This video is part of the 2021 Rosetta Antibody Virtual Workshop put on by the Meiler Lab at Vanderbilt University, in collaboration with the RosettaCommons
More information about this Workshop: https://structbio.vanderbilt.edu/work...
More tutorials from the Meiler Lab: http://meilerlab.org/index.php/rosett...
Rosetta resources: https://www.rosettacommons.org
Contents:
0:00 – Introduction
3:34 – Tutorial A Intro
6:29 – Tutorial A1, Sequence Design
12:25 – Tutorial A2, Graft Design
17:50 – Tutorial A3, Basic De Novo Run
19:54 – Tutorial A4, RosettaScripts RAbD Framework Components
26:49 – Tutorial B1, Optimizing dG
30:29 – Tutorial B2, Optimizing Interface Energy and Total Score
35:11 – Tutorial C1, RosettaDocking
42:36 – Tutorial C2, Auto Epitope Constraints
46:39 – Tutorial C3, Specific Residue Epitope Constraints
51:38 – Tutorial D1, CDR Instruction File
56:16 – Tutorial D2, Dissallow AAs and the Resfile
1:00:16 – Tutorial D3, Mintype
1:03:57 – Tutorial D4, Framework Design
1:08:44 – Tutorial D5, H3 Stem, kT and Sequence variability
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