MGUS & Sjogren's: The Hidden Crisis Explained

Learn the latest on Sjogren's MGUS progression, early myeloma warning signs, and how to catch hidden risks before it's too late. Featuring advanced imaging, dynamic monitoring, and the newest clinical trials for 2025

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Chapters:
00:00 Introduction
00:44 The Blood Test Traps
01:04 The Kappa/Lambda Ratio Paradox
01:40 Inflammation's Double Agent
02:08 Section 2: Imaging That Outsmarts Myeloma
02:25 Whole Body MRI: Silent Killer Detector
03:07 Dental X-Rays: Mouth as a Warning System
03:33 Section 3: When Treatments Backfire
03:43 The Rituximab Paradox
04:18 The Cold Blood Deception
04:43 Section 4: Silent Triggers
04:57 Dental Infections & Myeloma Growth
05:19 Night Sweats: Not Just Autoimmune
05:42 Section 5: Your Anti-Progression Toolkit
06:16 Lifestyle Interventions That Matter
07:01 Section 6: The Future is Now
07:55 CAR-T Trials in High-Risk MGUS
08:12 Microbiome Modulation
08:29 Final Section: Your 3-Step Survival Plan

Research Backing This Video: https://drive.google.com/file/d/1idXf...

To verify this information, you could easily cross-reference it with reputable sources such as:

Blood Advances – Rheumatologic diseases impact the risk of progression of MGUS to Multiple Myeloma
🔗 https://ashpublications.org/bloodadva...
ASH Publications

International Myeloma Working Group (IMWG) – Updated Diagnostic & Imaging Criteria
🔗 https://www.myeloma.org/imwg-publicat...
International Myeloma Foundation

Lancet Oncology (via PubMed) – Radiographic Patterns of Multiple Myeloma in the Jawbones
🔗 https://pubmed.ncbi.nlm.nih.gov/29703...
PubMed

Hong Kong Medical Journal – “Cryoglobulinaemia: Clinical and Laboratory Perspectives”
🔗 https://www.hkmj.org/system/files/hkm...
HKMJ

Mayo Clinic Cancer Blog – Smoldering Multiple Myeloma: Progression & Latest Research
🔗 https://cancerblog.mayoclinic.org/202...
Mayo Clinic Cancer Blog

Myeloma Society (PDF) – “Risk Factors for Progression in MGUS and SMM” (Rajkumar)
🔗 https://www.myelomasociety.org/wp-con...
myelomasociety.org

National Institutes of Health (PMC) – Hypophosphatemia in Patients With Multiple Myeloma
🔗 https://pmc.ncbi.nlm.nih.gov/articles...
PMC

PubMed – Mediterranean-Style Diet Lowers C-Reactive Protein (PREDIMED study)
🔗 https://pubmed.ncbi.nlm.nih.gov/16818...
PubMed

NIH PMC – Effects of Mindfulness-Based Interventions on Salivary Cortisol
🔗 https://pmc.ncbi.nlm.nih.gov/articles...
PMC

New England Journal of Medicine – Daratumumab for High-Risk Smoldering Multiple Myeloma (AQUILA Trial)
🔗 https://www.nejm.org/doi/full/10.1056...
New England Journal of Medicine

NEJM – Teclistamab in Relapsed or Refractory Multiple Myeloma
🔗 https://www.nejm.org/doi/full/10.1056...
New England Journal of Medicine

NEJM – Ide-cabtagene Vicleucel vs. Standard Regimens in Relapsed Multiple Myeloma
🔗 https://www.nejm.org/doi/full/10.1056...
New England Journal of Medicine

PubMed – Autologous Faecal Microbiota Transplantation to Improve Outcomes after Stem-Cell Transplant
🔗 https://pubmed.ncbi.nlm.nih.gov/38137...
PubMed

PubMed – DHA (Omega-3) Suppresses Macrophage Inflammasome Activation via NF-κB Inhibition
🔗 https://pubmed.ncbi.nlm.nih.gov/24911...
PubMed

PubMed – Rituximab B-Cell Depletion in Primary Sjögren’s Syndrome (Review Article)
🔗 https://pubmed.ncbi.nlm.nih.gov/31464...


⚠️ The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a medical consultation. Any comments and/or recommendations made in the comment section by anyone other than Discovery Unlocked does not reflect our opinion or recommendation.

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