Answers from the Experts: Q&A - October 2025

Do you have questions about cutaneous lymphoma and/or treatments? Our clinical Q&A's are a great way to learn more and empower yourself with knowledge from experts in their field.

Clinical Panel
Neha Mehta-Shah, MD, Washington University School of Medicine
Amy Musiek, MD, Washington University School of Medicine

Timestamps
03:40 What are the new drugs for Sezary syndrome? Are they in trials?
05:29 I suspect that the patches on my inner thighs are there because those areas never get any light even in the summer. Are there available medical grade narrowband UVB devices for home use that are available in the UK? And what are the risks of skin cancer using narrowband UVB? I understand it's pretty low, but is that correct?
07:04 Phototherapy is working to clear some spots, but new patches keep occurring. Is it reasonable to combine methotrexate with narrowband UVB?
8:02 What type of chemo is best for T-cell lymphoma? Why does the skin look like a burn victim's skin?
10:32 I was diagnosed with CTCL in 2021 at age 78. At stage MF/1A, what is the expectation or probability of progression and are any treatment options that could lead to total remission?
12:06 What stage does or should treatment start?
14:27 Which treatment responds better to Sezary, lacutamab or mogamulizumab?
15:14 I was diagnosed with subcutaneous panniculitis T-cell lymphoma with HLH (Hemophagocytic Lymphohistiocytosis) and I haven’t heard much about this type of cancer and research about this subtype. Can you explain more about it?
18:05 I would like to better understand gamma delta CTCL. What are some newer treatment developments to deal with this disease? How successful is stem cell transfer for gamma delta CTCL in middle-aged individuals?
19:53 I have essential thrombocytosis which may have recently morphed into polycythemia vera (MPN). I received my diagnosis of MF in February of this year. I am in the very initial part of my treatment - steroid ointment. who is the lead medical professional do I look to for my treatment – a dermatologist or hematologist?
21:49 I have lymphomatoid papulosis, Hodgkins and mycosis fungoides. Are these all stemming from the same underlying issue?
23:51 I was reading about new treatments such as Lymphir…what are some new treatments you’re excited about?
25:51 At what time frame do you begin to see bexarotene oral capsules work in follicular mycosis fungoides? Does bexarotene permanently damage cholesterol and thyroid levels? What other major side effects have you noticed with bexarotene oral capsules?
27:36 Do you support the use of alternative medicine such as the use of herbs and acupuncture treatments? Are they effective? Are there some alternative medicine treatments that you would advise against using?
29:55 Is there a risk of infection with Duvelisib medication?
31:26 Do the USA and UK share information and treatment methods?
32:58 I need to decide on a treatment option: Valchlor versus NB-UVB. I also have essential thrombocytosis and currently take Hydroxyurea. If choosing light treatment, I will need to work with my hematologist to find an alternate medication for my ET?
35:16 What are the COVID implications for this season, such as vaccine and antiviral use?
37:45 In MF, are there common antigens that the malignant clonal T cells are responding to?
39:59 I have LyP (lymphomatoid papulosis), MF and currently undergoing treatment on one node for Hodgkins lymphoma. Are there risk of HL returning again with underlying LyP and MF? Can stress increase occurrences?
42:34 Are there any effective treatments besides rituximab for a B-cell lymphoma?
45:08 I have a rare form of cutaneous lymphoma, Primary Cutaneous Peripheral T-Cell Lymphoma-Not otherwise specified (PC PTCL-NOS). I would like to know what research is being done to find treatments for those of us who do not qualify for transplants.
46:55 In MF, what is causing the itching in places where there is no plaques, patches, or redness?
48:02 Is there anything to help with the itching?
49:06 How will I know if my mycosis fungoides goes beyond my skin?
50:44 I developed pancreatitis after being on bexarotene for about 6 years. Do you think the bexarotene is the cause of the pancreatitis? What is a good alternative to bexarotene?
52:22 What's the difference from CTCL and cutaneous peniculitis t cell lymphoma?
52:49 Is there any data on how successfully stem cell transfer is for cutaneous peniculitis T-cell lymphoma patient?
53:25 Why is it so difficult to diagnose cutaneous lymphoma?
54:36 Is following an anti-inflammatory diet advised/recommended for those of us with cutaneous T-cell lymphoma? Does diet have anything to do with flares?
55:25 How long does it usually take treatment to clear the skin completely of FM T-cell cutaneous lymphoma plagues? I have been under treatment for almost 16 months.