Cariad Knight - Can 31P ssNMR Take Center Stage in Quantitative MRI of Membrane Morphology?

Quantitative Magnetic Resonance Imaging Conference: Validation of Quantitative MRI techniques (November 29th-December 1st 2023)

Validation of qMRI measurements (part 1) - Short talk

Cariad Knight - Lights, Camera, Myelin: Can 31P ssNMR Take Center Stage in the Quest for Quantitative MRI of Membrane Morphology?

Biography: MSc student in physics, University of British Columbia, Canada

Abstract: Improved sensitivity to myelin membrane changes can be achieved with phosphorous (31P) solid-state NMR (ssNMR) by cross polarization (CP) with hydrogen (1H). Experiments on pig neural tissues show that 1H/31P CP signals are highly sensitive to variations in abundance and orientation of myelin membranes. And by a two-step magnetization transfer process, we establish the potential of 1H/31P CP as a quantitative MRI metric uniquely poised to detect subtle changes in myelin membrane morphology.

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Organizing Committee

Dr. Mallar Chakravarty (@mallarchkrvrty1)
Dr. Christine Lucas Tardif (@tardiftweets)
Dr. Christopher Rowley (@rowleycd)
Dr. Aurélie Bussy (@AurelieBussy)
Olivier Parent (@oparent41)
Sajjad Feizollah (@SajjadFeizollah)
Mark Nelson (@Mark_Cameron_)