Death Blow to Origin of Life Research, Interviewing Chemist on Hydrothermal Vents & Miller Urey

Chemist Ed Peltzer, a former student of Jeffrey Bada and Stanley Miller, discusses the deep challenges of origin-of-life research. He critiques hydrothermal vent and Miller-Urey models, highlighting the overwhelming chemical complexity and hurdles of achieving life’s building blocks without guided intervention.
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00:00 Constrained chemistry and meteorites
03:10 Ed Peltzer’s background and mentors
06:07 Deep-sea research and spectrometer tools
09:31 Meteorites and amino acid discoveries
17:20 Life in labs before the email era
24:05 Maillard reactions and messy chemistry
30:48 Challenges with Miller-Urey products
33:13 Critique of hydrothermal vent theories
39:38 Amino acids and nucleotides instability
46:57 Fatty acids and stereochemistry issues
49:33 Problems with sugar synthesis pathways
56:45 Difficulties in polymer formation
58:59 Nucleotides and sugar problem unsolved
01:01:06 Growing complexity in biochemistry
01:05:19 Failure of liposome-based models
01:08:01 Time does not solve abiogenesis issues
01:10:25 Reflections on Miller-Urey legacy