The MS Severity Gene Explained by Neurologist

Genes are known to affect the risk of multiple sclerosis but were not thought to affect the severity of MS…until now. This genome wide association study reports that the rs10191329 allele in the DYSF–ZNF638 locus is linked to worse MS Severity (shorter median time to walking with a cane by 3.7 years along with increased brainstem and cortex pathology). This video reviews the article and implications for people with MS.

Selected Sources:

The article I am discussing: If you need a link, ask me on twitter (I do not have permission to post it publicly)
Multiple Sclerosis Risk Variant HLA-DRB1*1501 Associates with High Expression of DRB1 Gene in Different Human Populations: https://www.ncbi.nlm.nih.gov/pmc/arti....
Is multiple sclerosis progression associated with the HLA-DR15 haplotype?: https://www.ncbi.nlm.nih.gov/pmc/arti...


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.