CAR T-cell therapy (chimeric antigen receptor) ; Definition, How it works, Conditions treated with

CAR T-cell therapy is a revolutionary form of immunotherapy that modifies a patient's own T-cells to recognize and attack cancer cells. It is primarily used for blood cancers, such as leukemia and lymphoma.

How CAR T-cell Therapy Works
T-cell Collection – T-cells are extracted from the patient's blood.

Genetic Modification – A chimeric antigen receptor (CAR) is added to the T-cells, enabling them to target specific cancer antigens.

Cell Expansion – The modified T-cells are multiplied in a lab.

Infusion – The CAR T-cells are reintroduced into the patient’s bloodstream.

Cancer Cell Destruction – The engineered T-cells recognize and kill cancer cells.

Indications for CAR T-cell Therapy
B-cell acute lymphoblastic leukemia (ALL)

Diffuse large B-cell lymphoma (DLBCL)

Mantle cell lymphoma

Multiple myeloma

Potential Side Effects
Cytokine Release Syndrome (CRS) – Excessive immune response causing fever, low blood pressure, and organ dysfunction.

Neurological Toxicity – Confusion, seizures, or encephalopathy.

Infections – Due to immune suppression.

#CARTcelltherapy