Judith Campisi, Ph.D. on Cellular Senescence, Mitochondrial Dysfunction, Cancer & Aging

Dr. Rhonda Patrick interviews Dr. Judy Campisi, a professor of biogerontology at the Buck Institute for Research on Aging, a co-editor in chief of the Aging Journal and an expert on the role of cellular senescence in the aging process and development of cancer.

Cellular senescence is so important when we discuss aging and cancer because as our cells accumulate damage, which naturally happens as we age (even as a consequence of the energy generating processes and immune cell activation), there's only so many outcomes that we can expect. The first possibility is that the cells can die. The next is that they can become senescent where they stop dividing but stay alive all-the-while secreting molecules that influence surrounding tissue… or the worst of all possible outcomes, the cells can really go off the rails and become malignant.

What's interesting is that, while accumulating senescent cells is inevitable, there are varying strategies of how to tackle senescence and this is of great interest to the field of aging. There are ways to clear out senescent cells with drugs or even dietary and lifestyle interventions.

Not only are there ways to kill senescent cells, there are also ways to influence what sort of molecules they produce, possibly limiting the inflammatory ones… even without killing them.

In this podcast, Dr. Campisi shares with us many insights on how senescence may be key to our understanding of cancer and aging.

EPISODE LINKS:
Show notes and transcript: https://www.foundmyfitness.com/episod...
Dr. Judith Campisi's Lab @ Buck: http://www.buckinstitute.org/campisiLab

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Chapters:
00:00:00 - Introduction
00:00:52 - Drivers of aging
00:02:40 - Inflammation
00:08:06 - Senescence
00:18:57 - Lifespan vs healthspan
00:25:20 - Drivers of senescence
00:30:34 - Combating senescence with fasting
00:42:17 - Exercise extends lifespan
00:48:50 - Measuring senescence
00:54:45 - NAD+ boosters
00:56:00 - Fasting mimetics
00:57:00 - Cancer in animals

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PODCAST:
Apple Podcasts: https://podcasts.apple.com/us/podcast...
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