Is Double Antimicrobial Coverage Needed... And How To Assess These Duplicate Therapies

Double antimicrobial coverage or therapeutic duplication refers to regimens in which antimicrobial agents with overlapping spectrum are used.

In most instances, double coverage is not needed (such as double anaerobic coverage when 2 agents with adequate anaerobic coverage is employed - e.g. piperacillin/tazobactam and metronidazole).

In this video, I discuss how to assess these therapeutic duplications to optimize your patients' antimicrobial regimen in order to reduce adverse effects, antimicrobial resistance, and cost.

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Reference:
Ontario Agency for Health Protection and Promotion (Public Health Ontario). Antimicrobial Stewardship Strategy: Targeted review of redundant therapy or therapeutic duplication. Toronto, ON: Queen’s Printer for Ontario; 2016.

Disclaimer: The information in this video represents my opinion only. Please use your clinical judgement before applying the information presented in this video to your patients as every patient scenario is different. Medical evidence also evolves quickly and the evidence presented in this video may be outdated by the time it is published. Before using the information presented in this video to your practice, ALWAYS check the original references and conduct a literature search to see if there are updates to the recommendations based on new evidence. I do not accept responsibility for any harms from the use of the information in this video to make medical decisions. This video constitutes my own thought process and views, and do not reflect those of my employer, organization, committee, or other group or individual.