SSRI Differences (Sertraline Escitalopram Citalopram Fluoxetine Fluvoxamine Paroxetine)

Explore the differences between SSRIs, including Sertraline, Escitalopram, Citalopram, Fluoxetine, Fluvoxamine, and Paroxetine.
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The video provides a detailed comparison of six Selective Serotonin Reuptake Inhibitors (SSRIs): Sertraline (Zoloft), Escitalopram (Lexapro), Citalopram (Celexa), Fluoxetine (Prozac), Fluvoxamine (Luvox), and Paroxetine (Paxil). It highlights their pharmacokinetic and pharmacodynamic properties, including receptor interactions, FDA approvals, off-label uses, and potential side effects. Sertraline primarily blocks serotonin reuptake and is beneficial for atypical depression but may cause diarrhea. Escitalopram is the purest SSRI, causing minimal side effects, but may slightly increase QTc interval. Citalopram has a racemic mixture with antihistaminergic properties and may prolong QTc interval. Fluoxetine is known for its long half-life, suitability for bulimia, and activating properties, while Paxil has antimuscarinic effects, is linked to birth defects and dementia, and has a notorious discontinuation syndrome. Each drug is summarized with its unique characteristics, FDA approvals, and notable side effects, providing a comprehensive understanding of their differences and clinical applications.

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#depression #ssri #psychopharmacology

00:00 The More You Know (About Pharmacology) The Better
00:10 Introducing the 6 SSRIs
01:05 Sertraline (Zoloft)
03:56 Escitalopram (Lexapro)
07:12 Citalopram (Celexa)
08:35 Fluoxetine (Prozac)
11:11 Fluvoxamine (Luvox)
11:59 Paroxetine (Paxil)
13:20 One-liner Review