KIT D816V in People with Anaphylaxis and Mast Cell Activation Symptoms

In this episode of The Itch Review, we unpack the PROSPECTOR trial. Because clonal mast cell disease can be hard to diagnose, this trial helps answer an important question: Can a regular blood test help find clonal mast cell disease earlier in people with unexplained or very severe allergic reactions?

We review the article “Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation,” published in October 2025 in the Journal of Allergy and Clinical Immunology. Our hosts, Dr. Payel Gupta, Kortney, and Dr. Michael Blaiss, explain what the study found and what it means
for patients.

What you’ll learn:
• How mast cell activation can be clonal, allergic, idiopathic, or mixed
• What the KIT D816V mutation is and how to test for it
• How blood tests, tryptase levels, and HaT fit together
• Key results from the PROSPECTOR trial
• What these findings mean for patients with recurrent or severe anaphylaxis

📌 INFOGRAPHIC to follow along: https://drive.google.com/file/d/16wGB...

More episodes about Mast Cell Disease:
   • Do patients and providers see indolent sys...  
   • A Clinical Yardstick for Managing Mast Cel...  
   • A Clinical Yardstick for Managing Indolent...  
   • Avapritinib for Treatment of Indolent Syst...  

Thanks to Blueprint Medicines for sponsoring today’s episode.
This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

Allergy, Asthma & Immunology Innovations Podcast
Allergy & Asthma Network partners with The Itch Podcast to produce podcast episodes and series covering a wide range of subjects related to asthma, allergies, immunology and eczema. Join Payel Gupta, MD and Kortney as they dive into the complexities of medical diagnosis, offering balanced episodes with both medical and patient perspectives to help you live a healthier life.

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