The Glymphatic System and the Importance of Sleep

The glymphatic system exists through the brain / central nervous system, and is responsible for delivery and removal of substances within the fluid surrounding the cells. The glymphatic system plays a central role in waste clearance within the brain utilizing cerebrospinal fluid. Only recently named and detailed, the important fluid transport system will be presented in terms of anatomy and function and the critical role this system plays in maintaining central nervous system health. The impact of brain injury on the functioning of the glymphatic system will be discussed. The association of this system’s functioning with the processes of sleep will also be presented, emphasizing the importance establishing and maintaining healthy sleep routines. Lastly, recommendations and routines supportive of healthy sleep will be presented.

Learning objectives: Attendees of this presentation will be able to:

1) Define the major components and function of the glymphatic system.
2) Identify the relationship of glymphatic function with sleep.
3) Describe healthy habits and environmental factors that are supportive to better sleep.

Presentation Outline:
I. Describing the brain’s glymphatic system, and it’s similarities with waste-clearing processes within the body.
a. Brief history of the description of the anatomy involved in the glymphatic system with emphasis on the recent description and detailing of the functioning of this system.
b. Anatomy of the various components of this system.
c. The unique process by which fluid is moved unidirectionally though this system.
d. Substances transported to and from brain cells by this system
e. The process of waste removal within the brain and eventual transport outside of the brain.
II. The role of sleep.
a. Traditional theories on the function of sleep.
b. The unique association between sleep and glymphatic system function.
c. The association of brain function disruption associated with sleep disturbances.
d. The association of sleep disruption and brain injury.
e. The importance of restoration and normalization of sleep cycles after brain injury.
III. Sleep hygiene
a. Review of research findings in general and specific populations.
b. Specific recommendations to support more restful and healthy sleep.