Role of human plasma metabolites in metabolic health from larger population-based studies

Dr. Sapna Sharma
Institute of Epidemiology, Research Unit of Molecular Epidemiology
Helmholtz Zentrum
Munich | Germany

Part of the webinar
Metabolomics India 2025

Title
Role of human plasma metabolites in metabolic health from larger population-based studies

Metabolic health, particularly obesity and type 2 diabetes, is increasingly recognized as the outcome of a complex interplay between genetic susceptibility and environmental exposures. Circulating blood biomarkers provide insights into systemic physiological processes, although they often represent composite signals originating from multiple tissues and organs. Numerous small molecules have been associated with metabolic traits and are subject to substantial genetic regulation. To investigate these relationships, we performed multivariable linear and logistic regression analyses, using metabolite levels as predictors and glycemic status as a key indicator of metabolic health, while adjusting for demographic and clinical covariates. Potential causal effects of omics traits on disease outcomes were further assessed using two-sample Mendelian randomization (2SMR). Our results highlight branched-chain amino acids (BCAAs), lipids, lipid metabolism, and inflammatory pathways as critical modulators of metabolic health, underscoring their potential as shared therapeutic targets for improving metabolic health outcomes.

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