What is ADME in Toxicology?

Understanding ADME in Toxicology: Absorption, Distribution, Metabolism, and Excretion

ADME—Absorption, Distribution, Metabolism, and Excretion—is vital in toxicology as it determines how chemicals and toxins interact with the human body. These processes are integral to evaluating drug safety, environmental exposures, and therapeutic effectiveness. Absorption refers to the entry of a substance into the bloodstream, while distribution is how it spreads to tissues and organs. Metabolism involves chemical changes that may detoxify substances or create more toxic by-products. Excretion focuses on removing these substances via urine, feces, or sweat.

By analyzing ADME, toxicologists predict toxicity levels, optimize drug doses, and develop strategies to manage poisoning. Whether assessing drug development or environmental safety, ADME provides critical insights into public health protection.

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