Virology Lectures 2024 #6: Synthesis of RNA from RNA

Host cells have no enzyme that can replicate viral RNA or make mRNA, so virus genomes must encode enzymes to carry out these processes. In this lecture we discuss the mechanisms of RNA synthesis by RNA dependent RNA polymerases, including priming of RNA synthesis, how mRNA and genomes are produced in infected cells, and the switch from synthesis of mRNAs to genomes, for negative strand RNA viruses, positive strand RNA viruses, and double-stranded RNA viruses.

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