Mastering Homology Modeling with Swiss-Model: A Complete Guide Including Validation

Explore the intricacies of protein structure prediction in our comprehensive tutorial on homology modeling using Swiss-Model. This video provides a step-by-step guide on predicting the 3D structure of Aflatoxin B1 aldehyde reductase member 4 (Q8NHP1) from Homo sapiens. Learn to retrieve protein sequences, submit them to Swiss-Model, interpret essential metrics like GMQE and QMEAN scores, and validate the model using a Ramachandran plot. Ideal for bioinformatics students, researchers, and enthusiasts interested in protein structure analysis.

Video Timeline:
Introduction to Homology Modeling
Overview of Swiss-Model
Retrieving Protein Sequence from UniProt
Submitting Sequence to Swiss-Model
Analyzing Modeling Results
Understanding GMQE and QMEAN Scores
Validating Model with Ramachandran Plot
Conclusion and Key Takeaways

Important Links:

Swiss-Model: https://swissmodel.expasy.org
UniProt Database: https://www.uniprot.org


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