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Integrated Solutions & Research Strategies for the Discovery of Targeted Protein Degraders
Автор: WuXi Discovery Services
Загружено: 2024-08-01
Просмотров: 769
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Using an event-driven pharmacology approach, targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms. This technology is enabling researchers to pursue targets that were previously considered undruggable and to address the resistance issue of small molecule inhibitors. Since 2016, WuXi AppTec has built a comprehensive TPD discovery service platform to investigate the full functional cycle of protein degraders - from binary/ternary complex formation to target ubiquitination and degradation.
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