Animal Physiology – Lecture 20: Hemostasis PART 2 | Fibrinogen & Clotting Cascade | CSIR NET LS
Автор: CSIR NET Simplified with Pooja
Загружено: 2025-12-31
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In this lecture, we explore Fibrinogen (Factor I), the liver-produced plasma protein central to blood clotting. Learn how the clotting cascade works through zymogen activation, proteolytic cleavage, and enzyme amplification to form a stable fibrin clot at the site of injury.
Key points covered:
How platelets expose procoagulant phospholipids (PF3) to accelerate clotting
Fibrinogen structure: two sets of Aα, Bβ, γ chains ((AαBβγ)₂) linked by 29 disulfide bonds
Molecular design that allows rapid conversion to fibrin strands by thrombin
Fibrinogen synthesis in hepatocytes, including ER assembly, glycosylation, and Golgi modifications
Clinical significance: low fibrinogen → bleeding, abnormal levels → liver disease, clotting disorders, inflammation
This lecture gives a concise, exam-focused understanding of fibrinogen, its molecular design, synthesis, and role in hemostasis, making it perfect for CSIR NET Life Science, MSc, and BSc students.
#Hemostasis #Fibrinogen #BloodClotting #ClottingCascade #Platelets #CSIRNETLifeScience #AnimalPhysiology #BloodCoagulation #FactorI #PhysiologyLecture
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