为什么安眠药服用过量会致死 魏秀娥 徐州矿务集团总医院

为什么安眠药服用过量会致死 魏秀娥 徐州矿务集团总医院
目前最常用的安眠药为苯二氮卓类，能结合GABA受体A亚型，使氯离子通道开放频率增加，从而促使更多的氯离子内流而达到抑制中枢系统的作用。安眠药小剂量镇静，中等剂量催眠，但是大剂量情况下产生心血管和呼吸抑制，同时松弛肌肉，严重者导致死亡。另外常见的如巴比妥类，作用机制稍有不同，但大剂量时也明显抑制呼吸而致死。所以，在选择安眠药的时候一定要到正规医院就诊，在医生的指导下选择不同的药物，进行针对性的治疗。

Why do sleeping pills cause death when overdosed
At present, the most commonly used sleeping pills are benzodiazepines, It can bind to GABA receptor a subtype, The open frequency of chloride channel is increased, So as to promote more chloride ions to flow in order to inhibit the central system. A small dose of sedative, Moderate dose hypnosis, But at high doses, cardiovascular and respiratory depression occurs, Relax your muscles at the same time, Serious cases lead to death. In addition, barbiturates are common, The mechanism of action is slightly different, However, in large doses, it can also inhibit respiration and cause death. So, When choosing sleeping pills, you must go to a regular hospital for treatment, Choose different drugs under the guidance of doctors, Carry out targeted treatment.