Why Evidence-Based Medicine Is So Hard — And Why It Matters

Evidence-Based Medicine (EBM) uses the 5 As of EBM and is the cornerstone of clinical training, but why is it so difficult to practice and teach consistently? In this deep dive, Dr. Busti unpacks the foundation of EBM, the five A’s, and why application often falls short in practice. Drawing from his training at Oxford and years of teaching across medicine, pharmacy, and nursing, he highlights misconceptions, barriers, and practical strategies to bridge the gap between evidence, education, and patient care.

This episode also uses a real-world case example—the ISIS-2 trial of aspirin in acute myocardial infarction—to illustrate how evidence should be understood and applied.

If you’ve ever felt overwhelmed by the complexity of critical appraisal, statistical interpretation, or integrating patient-specific factors, this discussion will help you see why the “why” matters just as much as the “how.”

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Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this content.