TMA in Practice: Clinical Case Presentations
Автор: USTMA Consortium
Загружено: 2025-11-12
Просмотров: 23
TMA in Practice: Clinical Case Presentations
Morgan Schoer and Anuja Java, November 5th, 2025
Panel Discussion (John Sperati, MD, MHS, David Kavanagh, BSc, MB, ChB, PhD, FRCP, Jean Francis, MD,
FASN, Carla Nester, MD, MSA, FASN, Spero Cataland, MD, Camila Masias, MD)
• Focus on timely diagnosis in these scenarios and use of anti-complement therapy -clinical
factors and their importance in making the acute, clinical diagnosis? Is there a hierarchy?
• Clinical course with supportive care (does improvement in
hemolysis/renal function without C5 inhibitor therapy sway you)
• No other possible explanation (no HTN, no systemic illness)
• Prior pregnancies or triggers without TMA
• How soon to initiate – How late is too late? Importance of TMA teams
• How long to continue
• Use of functional testing if useful in these scenarios – Modified Ham’s,
Endothelial assays etc.
• Role of classical pathway in those without mutations
• Unmet needs
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