Malignant Hyperthermia | Causes, Triggers, Treatment & Anesthesia

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📌 Episode Overview

In this episode, we cover Malignant Hyperthermia (MH) — a life-threatening pharmacogenetic disorder triggered by anesthetic agents. This high-yield topic is vital for anesthesiologists, ICU doctors, OR nurses, and medical students.

✅ Key Topics Discussed:

Pathophysiology – Abnormal calcium handling, ryanodine receptor mutation

Triggers – Volatile anesthetics, succinylcholine

Clinical Features – Rapid rise in ETCO₂, tachycardia, hyperthermia, muscle rigidity

Diagnosis – Early recognition, differential diagnosis, caffeine-halothane contracture test

Treatment – Dantrolene, supportive therapy, cooling, ICU care

Exam-Relevant Points – SAQ structured answer framework

🔎 Key Takeaways from this Episode:

🔥 Early Warning – Unexplained rise in ETCO₂ and tachycardia are first clues
💉 Definitive Treatment – Dantrolene is the drug of choice
🧠 Crisis Management – Stop triggering agents, hyperventilate with 100% O₂
🩺 Exam Strategy – Answer in headings: definition, triggers, features, treatment, prevention

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