Enclomiphene Explained: Can a Pill Really Replace Testosterone Injections?

Enclomiphene Explained: Can a Pill Really Replace Testosterone Injections?

Can enclomiphene, a selective estrogen receptor modulator (SERM), actually replace testosterone injections in men with low testosterone? In this video, Dr. Chancellor Harn, a licensed naturopathic doctor with expertise in hormone optimization and functional medicine, breaks down how enclomiphene works, when it's used, and how it compares to traditional testosterone replacement therapy (TRT).

Learn how enclomiphene stimulates endogenous testosterone production by acting on the hypothalamus and pituitary gland to increase LH and FSH, leading to increased intratesticular testosterone and preserved fertility. Dr. Harn explains the difference between enclomiphene and clomiphene citrate, including why enclomiphene may be preferred from both a mechanistic and clinical standpoint.

You’ll also gain insight into how enclomiphene may fit into different clinical use cases, what sets it apart from other treatment options, and the physiological rationale behind its use in select patient populations.

▶️ If you're researching alternatives to testosterone injections, or trying to understand how to stimulate your own testosterone production without shutting down your HPG axis, this video is essential viewing.

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⏱ Video Chapters:
0:00 – Introduction
0:21 – What Is Enclomiphene?
0:59 – From Clomiphene Citrate to Isolated Enclomiphene
1:46 – Lower Side Effects and Endogenous Testosterone Boost
2:41 – How Enclomiphene Works: MOA and Testosterone Physiology
5:41 – Who Can Benefit From Enclomiphene? Secondary Hypogonadism Explained
7:16 – Fertility Preservation and HPG Axis Activation
8:21 – Can It Fully Replace Testosterone Injections?
9:21 – Psychological vs Physiological Effects: Enclomiphene vs TRT
10:51 – Does It Work? Yes, for the Right Patient
11:31 – Potential Side Effects of Enclomiphene
14:31 – Final Thoughts and Clinical Summary

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Medical Disclaimer:
This video is for general informational and educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Viewing this content does not establish a doctor–patient relationship. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition, hormone therapy, supplements, or treatment plans. Do not disregard professional medical advice or delay seeking it because of something you have seen or heard in this video.

Compensation Disclosure:
Some of the links provided in this description may lead to third-party platforms where I receive a commission or other financial benefit. This disclosure is made in accordance with applicable regulations concerning transparency and material financial relationships.