Acute Inflammation 3 (Pathoma 8)

Title: Acute Inflammation – Oxygen-Dependent Killing | Pathoma Chapter 2 Explained

Description:

In this video, we delve into the oxygen-dependent killing mechanism employed by neutrophils during acute inflammation, as outlined in Pathoma Chapter 2.
We'll explore the step-by-step process of how reactive oxygen species are generated to destroy phagocytosed microbes within the phagolysosome.

Key Topics Covered:

The oxidative burst and its role in microbial killing

Enzymatic conversions:

NADPH oxidase converting O₂ to superoxide (O₂⁻)

Superoxide dismutase (SOD) converting superoxide to hydrogen peroxide (H₂O₂)

Myeloperoxidase (MPO) converting H₂O₂ to hypochlorous acid (HOCl)

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The significance of HOCl (bleach) in pathogen destruction

Clinical relevance: Understanding Chronic Granulomatous Disease (CGD) and its association with defective NADPH oxidase


This video is ideal for medical students and professionals seeking a clear and concise explanation of this crucial immune response mechanism.

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