Genetic Or hereditary cases Or Causes Of Breast Cancer ; BRCA1, BRCA2, PALB2, TP53, CHEK2

Genetic or hereditary factors play a significant role in some cases of breast cancer. Here's an overview:

Key Genetic Causes
BRCA1 and BRCA2 Mutations:

These are the most well-known genetic mutations linked to breast cancer.

Women with these mutations have up to a 60% lifetime risk of developing breast cancer2.

These mutations also increase the risk of ovarian and other cancers.

Other Gene Mutations:

TP53: Associated with Li-Fraumeni syndrome, increasing the risk of breast and other cancers.

PALB2: Raises breast cancer risk to 41-60%.

CHEK2, ATM, and CDH1: Also linked to increased breast cancer risk.

Family History:

Having a first-degree relative (mother, sister, or daughter) with breast cancer doubles the risk.

Multiple affected relatives or early-onset cases in the family suggest a hereditary component.

Genetic Testing
Genetic testing can identify mutations like BRCA1/BRCA2.

It is recommended for individuals with a strong family history of breast or related cancers.

Management for High-Risk Individuals
Increased Screening: Regular mammograms and MRIs.

Preventive Surgery: Options like mastectomy or oophorectomy.

Lifestyle Changes: Maintaining a healthy weight, limiting alcohol, and avoiding smoking

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