(41) Pharmacokinetic (Part-08) | Redistribution of Drug | Drug Redistribution | ADME | English

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Pharmacokinetic- “What does BODY 1 do to the DRUG 2” we have simple interchanged the BODY and DRUG to make a definition. And as per the definition, our body responds to any drug by giving ADME effects.
1. A Stands for - Absorption
2. D stands for - Distribution
3. M stands for - Metabolism
4. E stands for- Elimination

Drug distribution refers to the movement of a drug to and from the blood and various tissues of the body (for example, fat, muscle, and brain tissue) and the relative proportions of drug in the tissues. (See also Introduction to Administration and Kinetics of Drugs.)

When a drug is absorbed and enters the systemic circulation, it is naturally distributed throughout the fluid and tissues in the body. Drug distribution is a subject that is covered in a branch of pharmacology called pharmacokinetics.

Redistribution. Highly lipid-soluble drugs given by intravenous or inhalation methods are initially distributed to organs with high blood flow. Later, less vascular but more bulky tissues (such as muscle and fat) take up the drug—plasma concentration falls and the drug is withdrawn from these sites. If the site of action of the drug was in one of the highly perfused organs, redistribution results in termination of the drug action. The greater the lipid solubility of the drug, the faster its redistribution will be. For example, the anaesthetic action of thiopentone is terminated in a few minutes due to redistribution. However, when the same drug is given repeatedly or continuously over long periods, the low-perfusion and high-capacity sites are progressively filled up and the drug becomes longer-acting.

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