Effect of graft cellular content on outcomes in HLA-mismatched alloSCT with PTCy as GvHD prophylaxis
Автор: VJHemOnc – Video Journal of Hematology & HemOnc
Загружено: 2026-01-16
Просмотров: 9
Rémy Duléry, MD, PhD, Saint-Antoine Hospital, Sorbonne University, Paris, France & Dana Farber Cancer Institute, Boston, MA, discusses a study that investigated the effect of graft cellular content on outcomes in HLA-mismatched allogeneic stem cell transplantation (alloSCT) using post-transplant cyclophosphamide (PTCy) as graft-versus-host disease (GvHD) prophylaxis. The findings highlighted that donor age affects the CD4⁺:CD8⁺ ratio in the graft, and that CD4 count correlated with the incidence of cytokine release syndrome (CRS). Dr Duléry also notes that CRS appears to play a significant role in immune reconstitution and may contribute to the development of GvHD. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.
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